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Half of the subjects received 250 mg metronidazole and 375 mg amoxicillin three times a day for 7 days; the other half received a placebo. GCF samples were. Comparison of three 7-day pantoprazole-based Helicobacter pylori eradication regimens in a Mexican population with high metronidazole resistance. M Dehesa. For this purpose metronidazole and tinidazole were administered daily, initially given in one intake during five days at concentrations of 2.5, 5, 6.25, and 7,5. Group B (20 patients) was administered 500 mg of metronidazole 3 times a day and 500 mg of tetracycline 4 times a day, both during 7 days. 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