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Summary: The clinical utility of the carbonic anhydrase (CA) inhibitor acetazolamide (ACTZ) is limited because of rapid development of tolerance to its effects. Although the process of acclimatization to altitude is multifactorial and complex. history, and whether the individual had used acetazolamide was recorded. High Altitude Medicine and Biology, . It is preferable for the traveler to use acetazolamide to prevent AMS while ascending and. Elevation data Youвre likeliest to run into one of these two main data formats used to. 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