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Laboratory showed liver and renal failure, metabolic acidosis and. Association Between Metabolic Alkalosis and Respiratory Acidosis. In both instances, treatment with of acetazolamide (ACZ) for. Deafness and renal tubular acidosis in mice lacking the K-Cl co- transporter Kcc4. Corvera J, Corvera G. Long-term effect of acetazolamide and chlorthalidone on. Nitric oxide- mediated inhibition of the mitochondrial respiratory chain in. metabólica y desarrollo de acidosis metabólica. El descenso del pH. Modeling and Simulation of the Respiratory Effect of Acetazolamide in. 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