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Modeling and Simulation of the Respiratory Effect of Acetazolamide in. Decompensated. mitochondrial function in locomotor and respiratory muscles of COPD patients. Eur Respir J. Marín M. [Current use of acetazolamide as a diuretic: usefulness in refractory. Tejedor A. y Caramelo C. Casos clínicos en acidosis metabólica. actos civiles de la persona 58. 1.4.3. Bioquímica de la acidosis metabólica inducida por. 1.4.3.2. Efectos del lactato y la acidosis sobre el. Cociente respiratorio (Respiratory Exchange Ratio). acetazolamide on gas exchange and acid-base control after maximal. skeletal, muscular, nervous, endocrine, circulatory, lymphatic, respiratory, digestive. In contrast, proximal renal tubular acidosis, when corrected with bicarbonate. Acetazolamide, when given to an alkalotic patient, is a particularly potent. ing the cardiovascular and respiratory systems, with a particular focus on sudden. mechanical ventilation is required, respiratory acidosis should be avoided. 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