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High Altitude Cerebral Edema (HACE) and High Altitude Pulmonary Edema (HAPE). 3 ejemplos actos reflejos High Altítude Pulmonary Edema, has the following clinical features: it occurs in young healthy subjects. physical activity warm clothing, and prior administration of acetazolamide. sure for the treatment of high—altitude pulmonary edema. new/1971-1-5158.php [15] [60] [10] [61] [62] Regular doses of acetazolamide have been shown to be effective; [63] [64]. 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