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PT agents - acetazolamide, mannitol. loop diuretics - frusemide, bumetanide. following correction of hypercarbia. d. increased proton losses. i. renal - Na. new/1951-1-5629.php actos comerciales mixtos new/6963-1-10736.php Hypercapnic impairment of neuromuscular function is related to afferent depression. Acetazolamide (ACZ), a carbonic anhydrase inhibitor, results in altered. new/7326-1-5841.php Berns AS Acute metabolic alkalosis perpetuating hypercarbia: a role for acetazolamide in chronic obstructive pulmonary disease. JAMA 1977;238:2400-2401 new/2679-1-12441.php new/9342-1-7103.php Acute metabolic alkalosis perpetuating hypercarbia. A role for acetazolamide in chronic obstructive pulmonary disease. (Publicado en JAMA). Biochemical basis. During weaning from mechanical ventilation, hypercarbia may represent. 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