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Una disminución de la DIF se asocia a acidosis metabólica, mientras que un aumento de la misma. Acetazolamide-mediated decrease in strong ion difference. Hyperchloremic acidosis: the classic example of strong ion acidosis. Anesth. puede tratarse de una acidosis tubular renal. ( I o II). Paciente. and use of acetazolamide. In children. hyperchloremia and a normal plasma. 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