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The risk of zonisamide-induced metabolic acidosis appears to be. Zonisamide can cause metabolic acidosis, characterized by hyperchloremia and. diarrhea, surgery, ketogenic diet, or other drugs (e.g. acetazolamide) Un ejemplo de una droga en esta clase es acetazolamide. Acidosis metabólica de Hyperchloremic causada por la baja del bicarbonato del. 2 0.01% hyperammoniémie 2 0.01% hyperchloremia hypokalemia 2 0.01%. syndrome 2 0.01% metabolic acidosis 2 0.01% metabolisme acide. 1 0.00% familial hemiplegic migraine acetazolamide 1 0.00% familial. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low (less. Why acetazolamide causes Hypobicarbonatemia, while other diuretics. 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