heavy metals d) Carbon anhydrase inhibition: acetazolamide, sulfanylamide, mafenide. For this reason, it has also been called “mixed” renal tubular acidosis. by the presence of hyperchloremic and hypokalemic metabolic acidosis with. Whereas acetazolamide caused a bicarbonate diuresis and a hyperchloremic metabolic acidosis, celecoxib appeared to have no detectable effect on renal. The use of acetazolamide for the treatment of Meniere's syndrome1,2 is uncommon. The cases of metabolic acidosis with a normal anion gap (hyperchloremic). The risk of zonisamide-induced metabolic acidosis appears to be. 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