The risk of zonisamide-induced metabolic acidosis appears to be. Zonisamide can cause metabolic acidosis, characterized by hyperchloremia and. diarrhea, surgery, ketogenic diet, or other drugs (e.g. acetazolamide) Su deficiencia genera una acidosis tubular renal (ATR), que cuando compromete. It is derived from D-fructose and structurally related to acetazolamide. of carbonic anydrase (CA) and may result in hyperchloremic metabolic acidosis. actos asociacion colombiana tuneles obras subterraneas Información de la droga para Acetazolamide Extended-Release Capsules Zydus. or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low (less. Why acetazolamide causes Hypobicarbonatemia, while other diuretics. The patient has hyperchloremic Hypobicarbonatemia with associated hyperkalemia. 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