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IN TYPE 2 RTA. ➢ Metabolic acidosis in and of itself. hyperchloremia and a normal plasma anion gap (Na+ - [Cl-. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low (less. Why acetazolamide causes Hypobicarbonatemia, while other diuretics. The patient has hyperchloremic Hypobicarbonatemia with associated hyperkalemia. 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