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Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute. Acetazolamide efficacy in hypokalemic periodic paralysis and the predictive. new/1655-1-21574.php Three patients with Hypokalemic Periodic Paralysis (HOPP)-associated. or worsened by acetazolamide, responded favorably to dichlorophenamide, a more. tornos del músculo: la parálisis periódica con o sin cambios del potasio,miastenia o desordenes miastenicos. Alteration of Ca channels cause muscle dysfunction periodic paralysis with or without. tion in acetazolamide-responsive myotonia congenita, pa- ramyotonia congenita and hyperkalemic periodic paralysis. Because clinical signs and endoscopic findings were suggestive of hyperkalemic periodic paralysis (HPP), acetazolamide treatment was instituted. 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