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Urinary. causing variable hyperchloremic, hypokalemic, sus- tained metabolic acidosis, a. mic muscle paralysis, periodic paralytic attacks, and chronic persistent. new/6250-1-20984.php La parálisis periódica es una rara condición heredada que causa episodios ocasionales de debilidad muscular severa. Hyperkalemic periodic paralysis. responsive to acetazolamide (AZM). Hyperkalemic periodic paralysis type 1 (hyperPP1) is characterized by attacks of flaccid limb weakness. Alterations in this channel produce flaccid paralysis, arrhythmias, impaired skeletal. correlation and therapeutic rationale in hyperkalemic periodic paralysis. 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