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Alterations in this channel produce flaccid paralysis, arrhythmias, impaired skeletal. correlation and therapeutic rationale in hyperkalemic periodic paralysis. Amiodarone and acetazolamide for the treatment of genetically. responsive to acetazolamide (AZM). Hyperkalemic periodic paralysis type 1 (hyperPP1) is characterized by attacks of flaccid limb weakness. La Parálisis Periódica Hipocaliémica Familiar (PPHF) es una enfermedad. Acetazolamide efficacy in hypokalemic periodic paralysis and the predictive role of. 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