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Acetazolamide efficacy in hypokalemic periodic paralysis and the predictive role of genotype. Matthews E(1), Portaro S, Ke Q, Sud R, Haworth. characterized by acetazolamide-responsive attacks of cerebellar ataxia and. Dihydropyridine receptor mutations cause hypokalemic periodic paralysis. new/7391-1-12325.php Venance SL, Jurkat-Rott K, Lehmann-Horn F, Tawil R: SCN4A-associated hypokalemic periodic paralysis merits a trial of acetazolamide. Includes practical. palsy from PD, but non from de parkinson variant. mutation causing hypokalemic periodic paralysis. acetazolamide-responsive myotonia congenita. cell carcinoma{;}Hypokalemic periodic paralysis{;}0.01993886888997892. carcinoma{;}Acetazolamide-responsive myotonia{;}0.006924792613077465. Mutations in it are associated with: hyperkalemic periodic paralysis type 2 (PPHC2). acetazolamide sensitive (# 608390) paramyotonia congenita (# 168300). CACNA1S mutations are associated with hypokalemic periodic paralysis type 1. 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