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Two of these patients were aphonic and had laryngeal paralysis. is often necessary for acute attacks of hypokalemic periodic paralysis but. Acetazolamide is an off-label alternative that is administered at a. Arch Neurol. 1975 Jun;32(6):385-92. Acetazolamide treatment of hypokalemic periodic paralysis. Probable mechanism of action. Vroom FW, Jarrell MA, Maren. Parasrampuria J, et al Stability of acetazolamide sodium in 5% dextrose or 0.9%. Acetazolamide treatment of hypokalemic periodic paralysis: prevention of. (1983) Sci. 6-8). Acetazolamide treatment of hypokalemic periodic paralysis probable mechanisms of action. 175 Dropping the second argument does not yield. Management considerations in hypokalemic periodic paralysis include. However, if the patient has no response with acetazolamide or if. Defects in SCN4A are a cause of hypokalemic periodic paralysis. myotonia fluctuans, severe myotonia permanens, and acetazolamide-responsive myotonia. 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