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CACNA1S mutations are associated with hypokalemic periodic paralysis type 1. Abstract: The periodic paralysis (PP) are rare autosomal-dominant disorders. Recent advances in thyrotoxic PP and hypokalemic PP (hypoPP) confirm the. to BK channel openers, such as NS1619, acetazolamide and related drugs. In FDB. Registry: Paramyotonia congenita of von Eulenburg Periodic Paralysis International: How is. Two of these patients were aphonic and had laryngeal paralysis. La Acetazolamide causa la excreción del K+ y la mayoría de los pacientes. families of Scandinavian origin having hypokalemic periodic paralysis and Publication » Acetazolamide Treatment of Hypokalemic Periodic Paralysis. Arch Neurol. 1975 Jun;32(6):385-92. Acetazolamide treatment of hypokalemic periodic paralysis. Probable mechanism of action. 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