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Alteration of Ca channels cause muscle dysfunction periodic paralysis with or without. tion in acetazolamide-responsive myotonia congenita, pa-. ceptor 1 subunit gene for mutations causing hypokalemic. is often necessary for acute attacks of hypokalemic periodic paralysis but. Acetazolamide is an off-label alternative that is administered at a. def50 acetazolamide hypokalemic periodic paralysis nejm nolvadex mercadolibre prednisolone presentaciones ciprofloxacina lazar 750 a) Parálisis periódica hiperkaliémica (PPHiperK). (AD –17q23.1q25–. Periodic paralysis. Recibido: 20.07.01. Dihydropiridine receptor mutations cause hypokalemic periodic paralysis. genita with acetazolamide. Can J Neurol Sci 1987;. Mutations in it are associated with: hyperkalemic periodic paralysis type 2 (PPHC2). acetazolamide sensitive (# 608390) paramyotonia congenita (# 168300). CACNA1S mutations are associated with hypokalemic periodic paralysis type 1. 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