pulmonary edema, non-feasible HBO (technical problems etc.), difficulty. Surrogate outcomes (EEG, cerebral blood flow reactivity to acetazolamide) examined. High Altitude Pulmonary Edema - HAPE is abnormal fluid accumulation in the lungs resulting. acetazolamide, niphedipine corticoids. Bibliografía q Acetazolamide: best prophylaxis of acute mountain sickness when slow ascent is not possible. High-altitude pulmonary edema. N Eng J Med. dence of high-altitude pulmonary oedema is approximately. 2%.32. 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