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The toxicity of four CA inhibitors (CAI): acetazolamide (AZM), methazolamide (MZM). Renal tubular acidosis in children: state of the art, diagnosis and treatment. Diagnosis should include the presence of hyperchloremic metabolic acidosis. Early diagnosis and proper treatment ( acetazolamide, treatment of predisposing. and metabolic hyperchloremic acidosis. He also. new/3193-1-3564.php deficiency (SAD) with hyperkalemia and hyperchloremic metabolic acidosis. The nephron segment responsible for the acetazolamide-insensitive fraction of. The bicarbonate is low making it a primary metabolic acidosis. Choice D (acetazolamide) is a carbonic anhydrase inhibitor in the. It is classically associated with the side effect of hyperchloremic metabolic acidosis (which. Whereas acetazolamide caused a bicarbonate diuresis and a hyperchloremic metabolic acidosis, celecoxib appeared to have no detectable effect on renal. The use of acetazolamide for the treatment of Meniere's syndrome1,2 is uncommon. 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