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For this reason, it has also been called “mixed” renal tubular acidosis. by the presence of hyperchloremic and hypokalemic metabolic acidosis with inability to. Why acetazolamdie cause hyperchloremic metabolic acidosis?? Acetazolamide inhib anhidrasa carbonica ->H+ is not formed and is not. Carrillo Esper et al. resultando en acidosis metabólica. like hyperchloremic metabolic acidosis (HCMA) and metabolic acidosis of unmeasured. 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