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These were not evaluated in the present study. perchloremic metabolic acidosis (HCMA) and metabolic. non-respiratory acid-base disturbance. Acetazolamide-mediated decrease in strong ion di-. Metabolic Alkalosis and Respiratory Acidosis. of chronic respiratory acidosis (RA). ment with 500 of acetazolamide (ACZ) for some days and. "Acetazolamide and Breathing", American Journal of Respiratory and Critical. metabolic acidosis and explaining a leftward shift of the CO2 response curve. 58. 1.4.3. Bioquímica de la acidosis metabólica inducida por. 1.4.3.2. Efectos del lactato y la acidosis sobre el. Cociente respiratorio (Respiratory Exchange Ratio). acetazolamide on gas exchange and acid-base control after maximal. [Efficacy of acetazolamide treatment of patients with hypercapnia and. 1996, with 45 patients who had chronic respiratory acidosis and metabolic alkalosis. 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