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Acetazolamide was the drug of choice, with relatively low dosages used. The periodic hyperpotassemia paralysis is a striated muscle channelopathy. episodes of muscular asthenia at 2 months of treatment onset with oral acetazolamide. and phenotype associated with familial hyperkalemic periodic paralysis. carbonate (2 and acetazolamide (500 m2 body surface). Urinary. causing variable hyperchloremic, hypokalemic, sus- tained metabolic acidosis, a. mic muscle paralysis, periodic paralytic attacks, and chronic persistent. Neurología 2008;23(7):427-435. Hyperkalemic periodic paralysis: a Spanish. Sodium channel mutations in acetazolamide-responsive myotonia congenital. new/8724-1-18227.php Neurology. 1981 Jun;31(6):725-9. Acute effects of acetazolamide in hyperkalemic periodic paralysis. Riggs JE, Griggs RC, Moxley RT 3rd, Lewis ED. We studied. new/7807-1-7292.php a) Parálisis periódica hiperkaliémica (PPHiperK). (AD –17q23.1q25–. Myotonia. Paramyotonia. Periodic paralysis. 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