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ICP management since it may cause hyperchloremic acidosis and. A randomized, double-blind, placebo-controlled trial of acetazolamide for the. Renal Tubular Acidosis Dr. Simon Onsongo Objectives ‡ Review causes of. gap: ‡ q Bicarbonate, o chloride ‡ Hyperchloremic acidosis ‡ Renal vs. high urine pH despite metabolic acidosis ± Type 2: think acetazolamide. Acetazolamide (a-set-a-ZOLE-a-mide), sold as Diamox and Avva, reduces the activity. A reduction in plasma bicarbonate results in metabolic acidosis, which. then passes into the bloodstream, creating a hyperchloremic metabolic acidosis. During stimulation of potassium excretion by NaHCO3, acetazolamide or. Hyperchloremic metabolic acidosis was recognized in all but 2 patients of each. However, this patient appears to have a hyperchloremic metabolic acidosis as well. 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