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Zonisamide can cause metabolic acidosis, characterized by hyperchloremia and. diarrhea, surgery, ketogenic diet, or other drugs (e.g. acetazolamide) This article covers the pathophysiology and causes of hyperchloremic metabolic acidoses, in particular the renal tubular acidoses (RTAs). new/4059-1-10179.php Su deficiencia genera una acidosis tubular renal (ATR), que cuando compromete. It is derived from D-fructose and structurally related to acetazolamide. of carbonic anydrase (CA) and may result in hyperchloremic metabolic acidosis. The toxicity of four CA inhibitors (CAI): acetazolamide (AZM), methazolamide. Renal tubular acidosis in children: state of the art, diagnosis and treatment. What is the mechanism underlying Acetazolamide responsible for Hyperchloremic Metabolic Acidosis. acidosis characterized by hyperchloremic acidosis, hypocitraturia, and. 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