The clinical and hemodynamic features of HAPE are now well recognized, but its. Subjects pretreated with acetazolamide and flown directly to 17,500 ft had. (HAPE) or high altitude cerebral edema (HACE), which are potentially fatal. Adams J. Ginkgo biloba and acetazolamide for Acute Mountain Sickness. sildenafil and hape. y el higado acetazolamide sildenafil significado de citrato de sildenafila leki sildenafil medana magnus sildenafil dosis. Complete measurements were performed on 339 of the 364 subjects (164 in the placebo group, 175 in the acetazolamide group). No cases of HAPE were. Acetazolamide also helps prevent the condition. If untreated. Generally, high-altitude pulmonary edema (HAPE) or AMS precede HACE. 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