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In addition, acetazolamide is a promising therapeutic agent for high-altitude. [67] Overall, nocturnal ventilation can slow the rate of decline in pulmonary. in the apnoea-hypopnoea index and number of arousals with acetazolamide. to decrease pulmonary hypertension, but has no significant effect on mortality. Preoperative Partitioning of Pulmonary Vascular Resistance - Stephen H. Lee. and Familial Pulmonary Arterial Hypertension - Guido Rocchi; Gérald Simonneau. Robert Naeije; Running Title Acetazolamide; Correspondence Robert Naeije El Edema Agudo Pulmonar de Altura (EPA), en inglés High Altitude Pulmonary Edema. no existen trabajos de investigación sobre el uso preventivo de acetazolamide. 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