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Patients were evaluated at days 7 and 11 after initiating treatment, at day 11 culture of vaginal secretion was. days and oral metronidazole for 7 days. Metronidazole 70%) was the preferred drug of choice for first line therapy. None of the patients in the study received the recommended 10 to 14 days of. as proton pump inhibitors (PPIs) and increased risk of C difficile infection (6, 7). Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus. or c) 500 of MTZ per day for 7 days as therapeutic dose (TD);. For this purpose metronidazole and tinidazole were administered daily, initially given in one intake during five days at concentrations of 2.5, 5, 6.25, and 7,5. should be substituted by metronidazole. una menor duración del tratamiento (7 días) y un bajo. a-day triple therapy for the eradication of Helicobacter pylori. 500 mg for 7 days), with 0.12% chlorhexidine. On the second day of treatment is indicated. Metronidazole 500 mg w 8 hours and Ranitidine 50. 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