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Acetazolamide has no role in the treatment of TPP. tirotóxica: Caso clínico Thyrotoxic hypokalemic periodic paralysis: Report of one case new/8709-1-11738.php The most common abnormality is metabolic alkalosis, hypokalemic metabolic. Familial hypokalaemic periodic paralysis occurs as an autosomal dominant. of spironolactone, and 250–750 acetazolamide. La parálisis periódica es una rara condición heredada que causa episodios ocasionales de debilidad muscular severa. Hyperkalemic periodic paralysis. Sodium channel mutations in acetazolamide responsive myotonia congenita, paramyotonia congenita, and hyperkalemic periodic paralysis. Paramyotonia congenita and hyperkalemic periodic paralysis are linked to the. Sodium channel mutations in acetazolamide-responsive myotonia congenita. Three patients with Hypokalemic Periodic Paralysis (HOPP)-associated. or worsened by acetazolamide, responded favorably to dichlorophenamide, a more. 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