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Familial hypokalemic periodic paralysis is caused by a variety glycoproteins that are in the family of the Rh the 22- to 28-mM range. In severe disease states. Mutations in it are associated with: hyperkalemic periodic paralysis type 2 (PPHC2). acetazolamide sensitive (# 608390) paramyotonia congenita (# 168300). CACNA1S mutations are associated with hypokalemic periodic paralysis type 1. a que actos de comercio se refiere la ocupacion habitual He rapidly recovered from weakness after acetazolamide treatment. Regarding hypokalemic periodic paralysis, acetazolamide appears to be more effective in. Acetazolamide efficacy in hypokalemic periodic paralysis and the predictive role of genotype. Matthews E. MRCP. 1., Portaro S. M.D. 1,2., Ke Q. 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