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Seroquel And Olanzapine Together 12) Lund C, Shafiei M, Molden E, Jacobsen D. Toxicokinetics of Quetiapine and its Active Metabolite N-desalkylquetiapine During Acute Poisoning. Clin Toxicol. Symptoms associated with intoxication were coma without arterial hypotension. The efficacy of quetiapine in the treatment of acute mania and. acute treatment of bipolar depression: a systematic review and. rapeutique, mais présenter une toxicité en rai-. Quétiapine 12,5-25 mg bid. Leur utilisation à long terme est toutefois limitée par leur toxicité. keywords : atypical antipsychotic drugs, clozapine, quetiapine, risperidone, olanzapine, acute. This liver toxicity can occur as a result of either a single acute large overdose. The reason behind quetiapine is effect on sleep appears to be due to its. and useful DMARD, largely because of lower drop-out rates for reasons of toxicity. 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