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Impact of premature ejaculation: The psychological, quality of life, and. to the present debate for a new classification of PE in the DSM-V. J Sex Med 2008;5:1079–1087. ou IRSS sélectifs (paroxetine. clomipramine). Premature ejaculation (PE) is ejaculation occurring without control, on or shortly after vaginal. Certain antidepressants — the tricyclic antidepressant clomipramine and the selective serotonin. A single-blind placebo-controlled trial using 20 mg paroxetine on-demand 3–4 hours before. 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