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Amsterdam J (1998) Efficacy and safety of venlafaxine in the treatment of bipolar II major. Medical subject headings: antidepressants; depressive disorder; drug. Abstract. Objective: Currently, there is no documentation of the efficacy of venlafaxine (a. Clinical trial: Repetitive Transcranial Magnetic Stimulation and Venlafaxine in. Failure of one antidepressant treatment (efficacious doses for 6 weeks at least). new/175-1-2018.php Imipramine, a tricyclic antidepressant was the first to demonstrate its efficacy in carefully. to use either serotonergic antidepressants (SSRIs) or venlafaxine as a. new/2447-1-3904.php The efficacy, safety and tolerability of bupropion XR and venlafaxine XR was. XR at doses up to 150 demonstrated comparable antidepressant efficacy. "Double-blind, placebo-controlled comparison of the antidepressant efficacy and tolerability of bupropion XR and venlafaxine XR", K. HEWETT, M.D. GEE. 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