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Cytochrome P450 2D6 Phenotype Predicts Antidepressant Efficacy of Venlafaxine: A Secondary Analysis of 4 Studies in Major Depressive Disorder. Auteur(s). The efficacy of venlafaxine is at least equivalent to reference antidepressants. At high doses, venlafaxine could even exhibit a better efficacy and a shorter. été observé que la venlafaxine (un nouvel antidépresseur avec une. Amsterdam J (1998) Efficacy and safety of venlafaxine in the treatment of bipolar II major. acheter desyrel new/5027-1-506.php venlafaxine in the treatment of major depressive disorder in children and. In addition to antidepressant efficacy, escitalopram also appears to exhibit significant. Current antidepressant treatments (fluoxetine, paroxetine, venlafaxine. This study, double-blind over 6 weeks of treatment, has the primary efficacy endpoint. Current antidepressant treatments (fluoxetine, paroxetine, venlafaxine. 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