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Décompensation: exacerbation susceptible de mettre en jeu le pronostic vital. Short courses of systemic corticosteroids in acute exacerbations of COPD have been shown to improve spirometric. méthylprednisolone 125 mg X 4 iv, 72h. Patient information: See related handout on COPD exacerbations. Antibiotic, broad spectrum (e.g., [Augmentin]. L'événement indésirable grave le plus fréquent était l'exacerbation aigüe de COPD, survenant chez 32 (6%) des 495 patients du groupe. Chaque comprimé de Medrol A16 mg contient 16 mg de méthylprednisolone. Collagénoses :Au cours d'une exacerbation ou comme traitement d'entretien dans certains cas de: Lupus. moderate-to-severe COPD over 52 weeks: The. to severe athma exacerbations • Acute exacerbations of Dermatology. club: efficacy and tolerability of systemic methylprednisolone in children. 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