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Long-term effects of jawbone curettage on the pain of facial neuralgia. The Journal of Bone and Joint Surgery. new/1638-1-4819.php Higher rates of serious emotional or health problems, including depression, anxiety. patients compared to 0.7% for alendronate-treated patients. rash, joint disease, joint pain, back pain, pain in arms or legs, flushing, fever, chills. Alendronate is used to treat and prevent osteoporosis (a condition in which the. should know that alendronate may cause severe bone, muscle, or joint pain. The patient suffers from fever, joint pain, and erythema that can be. alendronate in 70-milligram tablets, which were taken once weekly. 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