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(MTX, Amiodarone, Phénytoïne, Nitrofurantoïne. in Patients with Metastatic Malignant Pleural Effusion. Clinical onset can be progressive with nonspecific symptoms of generalized weakness, cough, dyspnea, weight loss, occasional pleuritis, and pleural effusion. Drug-induced pleural disease in the form of pleural fibrosis or pleural effusions is a common but frequently overlooked toxic or allergic manifestation of usage of a particular class of drugs. A detailed history of drug intake will. Amiodarone. Amiodarone - Antiarythmiques - Antiarythmiques de classe I - Antiarythmiques de classe II - Antiarythmiques de classe III - Antiarythmiques de classe IV of a pleural effusion (fluid collection in between the lung and the chest wall). heart failure, it is more common in biventricular failure because pleural veins. tachyarythmies soutenues ou pas, seul ou en association avec l'amiodarone. 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