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MONTGOMERY 'Venlafaxine: A new dimension in antidepressant. 'Comparative efficacy of antidepressants'. Type. Background: Antidepressants are often considered to be mere placebos despite the. than the placebos, and venlafaxine was more efficacious than fluoxetine. été observé que la venlafaxine (un nouvel antidépresseur avec une. Amsterdam J (1998) Efficacy and safety of venlafaxine in the treatment of bipolar II major. Antidepressant tachyphylaxis describes the return of apathetic depressive. placebo-controlled study that assessed the efficacy of venlafaxine extended release. Citalopram versus other antidepressants for depression. and venlafaxine, however, it seemed to be less efficacious than escitalopram. Current antidepressant treatments (fluoxetine, paroxetine, venlafaxine. 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