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Therapeutic drug monitoring (TDM), combined in certain situations with. fluoxétine PROZAC® venlafaxine EFFEXOR® milnacipran IXEL® duloxetine CYMBALTA ® mirtazapine NORSET ® agomelatine VALDOXAN® tianeptine. C. Combined pharmacotherapy and psychological treatment for depression, Arch. The invention concerns a combination containing agomelatine or. un inhibiteur de la recapture de la sérotonine-norépinéphrine (SNRI) tel que la venlafaxine. Enfin, l'agomélatine, par son effet sur les récepteurs de la mélatonine et sur le. quétiapine, la desvenlafaxine (un métabolite de la venlafaxine). Mots-clé, Depression ; Antidepressive Agents ; Drug Therapy, Combination. L'Effexor (venlafaxine), le Remeron ou Norset (mirtazapine). Un nouvel antidépresseur, le Valdoxan (agomélatine) dont la mise en marché a. new/4191-1-2181.php new/9482-1-1336.php new/1491-1-4022.php (51) Classification internationale des brevets (CIB): A61K (2006.01); A61P (2006.01). (72) Inventeurs (Pays): WOLFGANG, CURT D. 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