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N Engl J. with atrial fibrillation with aspirin plus clopidogrel :. new/8556-1-3295.php BACKGROUND: Vitamin K antagonists reduce the risk of stroke in patients with atrial fibrillation but are considered unsuitable in many patients. 8) Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular. control of atrial fibrillation stressed the impor- tance for safer. tions for atrial fibrillation ablation are broad- ening. 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