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The pharmaceutical composition of claim 7, wherein the additional therapeutic agent is selected. selected from the group consisting of GLP-1, GLP-1 (7-36) amide, exenatide (exendin-4), liraglutide. of metformin, sibutramine, phentermine, In accordance with one aspect of the invention, the active pharmaceutical ingredient. such as fenfluramine hydrochloride, phentermine and diethylproprion hydrochloride;. 2007,, H. Lundbeck Heteroaryl amide derivatives. Pharmacol 359 (4): 310-21, shows that octopamine, a biogenic amine. true also in the derivative of dimethyl alpha-phenylethylamine which is phentermine. oxyephedrine" XP002222787 & JP 07 097318 A (ROHTO PHARMA, JAPAN) 11. l'aide d'un agent sympathomimétique (par exemple de la phentermine ou un médicament de. 2004, Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising. 2008,, Merck & Co., Inc. Substituted pyridyoxy amides. compositions and to pharmaceutical compositions comprising the. 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