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If your Cipro tendon pain hasn't gone away by now, chances are it's not going to go. Monday - Sat 11:00AM - 6:00PM & Sunday's 12:00-5:00PM. Copyright © 2013 Perpetual Harvest. All Rights Reserved. Designed by cipro achilles tendon pain. Quinolone antibiotics (eg, ciprofloxacin, ofloxacin) can cause inflammation of tendons. Open surgical treatment of acute Achilles tendon ruptures significantly. Another patient had pain and swelling of one Achilles tendon 9 months after only a 1-week course of ciprofloxacin (500 mg bid). Biopsy of the tendon was done. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. 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