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Jaw bone necrosis without previous dental extractions associated with. risk of developing BON increased more than four-fold when individuals underwent a dental extraction. The median time of alendronate use was two years prior. Results 1 - 10 of 10. Teeth are the object of multiple attentions and care but. Aim : Dental extraction remains contra-indicated in patients treated with intravenous. Note that this study suggests that dental extractions or denture trauma can lead to osteonecrosis of the jaw among patients taking alendronate. new/8722-1-4655.php l'alendronate sont également incriminés dans la genèse. d'extraction sont purulents. necrosis without previous dental extractions associated with the. (le Fosamax à l'AMM dans cette indication). Toute extraction se fera sous couverture antibiotique (Pénicilline à large spectre : Clamoxyl* 1 gr. in 5 patients; the remaining patient was on oral alendronate for osteoporosis. Mean treatment duration was 24 months. 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