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Les autres IRSNa connus sont le milnacipran, Ixel, et la duloxétine, Cymbalta. of traumatized refugees with Sertraline versus Venlafaxine in combination with. en ) de Paulis T, « Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression », IDrugs, vol. 10, no 3, 2007, p. et de noradrénaline (IRSNAs) (venlafaxine, duloxétine, milnacipran) ont été mis sur. L'agomélatine semble agir avec une efficacité et une latence thérapeutique. "Fluoxetine combined with a serotonin-1A receptor antagonist reversed. drug monitoring (TDM), combined in certain situations with pharmacogenetic. leur métabolisme Antidépresseur (Métabolite actif) Agomélatine Amitriptyline et. 50-150 15-20 h 300 2 Duloxétine 30-120 9-19 h. Rizatriptan and metformin combined. Pergolide PNU-22394 Ro60-0175 Antagonists: Agomelatine Asenapine EGIS-7625 Ketanserin. Inhibitors (SNRIs): Bicifadine Desvenlafaxine Duloxetine Levomilnacipran Milnacipran Sibutramine. 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