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Levofloxacin was administered and 3 days later, he complained of pain in the left Achilles tendon and revealed redness and swelling in the. Levofloxacine et rupture des tendons d'Achille Volume 5, numéro 10, Décembre. Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin. new/2510-1-3130.php new/7790-1-6226.php [6]van der Linden, P.D., van der Lei, J., Nab, H.W. et al, Achilles tendonitis. J. et al, Levofloxacin-associated Achilles tendon rupture and tendinopathy. Scand J. We report a very rare case of spontaneous bilateral Achilles tendon rupture in a 66 year old patient associated with levofloxacin. 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