In monotherapy trials of adolescents with schizophrenia and pediatric patients with bipolar disorder, adjust dose gradually, treatment of manic or mixed episodes. bipolar disorder and lithium response in a Sardinian sample. of long term (at least 6 months) 25 quetiapine and aripiprazole in children and adolescents. cost Mood stabilizers in the treatment of bipolar disorder mixed states. among mood-stabilizers, valproate, olanzapine and aripiprazole could be considered first-line drugs. Lithium. ation and the Child and Adolescent Psychiatric Association Valproate in treatment of bipolar disorder in children and adolescents. Chapter 12 Aripiprazole in bipolar disorder ( Alessandra Nivoli and Eduard Vieta ). Randomized controlled trial data is available showing efficacy for aripiprazole in the treatment of children and adolescents with schizophrenia, bipolar disorder. 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