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The actual mechanism of action of aripiprazole, as with other drugs having efficacy in schizophrenia. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. THERAPEUTIC EFFICACY: The efficacy of aripiprazole has been demonstrated. Efficacy of aripiprazole-intramuscular-depot for the long-term maintenance treatment of schizophrenia. APA 2012; abstract NR6-41. new/49-1-13031.php Elderly: the effectiveness of ABILIFY in the treatment of schizophrenia and Bipolar I Disorder in patients 65 years of age or older has not been established. Fanapt iloperidone atypical antipsychotics Psychosis Schizophrenia. 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