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Kikuchi T, Altar CA, The antipsychotic aripiprazole is a potent, partial agonist at the. Selective antagonism at dopamine D3 receptors attenuates cocaine seeking. L. Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences. pragmatic randomized controlled trial on aripiprazole, olanzapine and. A novel strategy in order to regulate dopamine CNS circuitries is based on dopamine partial agonism. A dopamine partial agonist can be conceptualized as a. Aripiprazole has no appreciable affinity for cholinergic muscarinic receptors (IC50 > 1000 nM). [Aripiprazole functions as a partial agonist at the dopamine D2. Effect of aripiprazole augmentation of clozapine in schizophrenia: a. is a second-generation antipsychotic with high affinity for dopamine D(2), serotonin 5-HT(2A), 5-HT(2C), and α(1)-adrenergic receptors, and low affinity for other receptors. atypical and partial symptoms of full-blown mental disorders, often neglected. 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