This review examines the development of dopamine partial agonists as a new. with aripiprazole - a new antipsychotic, which shows partial agonist activity at. Aripiprazole: does partial dopaminergic agonism translate into clinical benefits?. Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic. Abilify is chemically different from other atypical antipsychotic medications such as Clozaril, Geodon, and Risperdal. It is a dopamine partial-agonist meaning. Abilify is the first third-generation antipsychotic (TGA) to hit the US market. TGAs are defined as being partial agonists at dopamine D 2. Aripiprazole is a partial dopamine agonist of the second generation class of atypical antipsychotics with additional antidepressant properties that is primarily. 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