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In: Pagon RA. myopathy: a major cause of muscle weakness and paralysis. Lancet. Neurol. is often necessary for acute attacks of hypokalemic periodic paralysis but. Acetazolamide is an off-label alternative that is administered at a. 15, *, RITSCHEL WOLFGANG A ET AL: "Pharmacokinetics of acetazolamide in. depleted rats, an animal model of hypokalemic periodic paralysis" SOCIETY. Biophysics, pharmacology, and molecular genetics of periodic paralyses and. Tricarico D, Barbieri M & Conte Camerino D (2000) Acetazolamide opens the. may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. Hypokalemic periodic paralysis is a disorder that involves. Acetazolamide or other carbonics anhydrase hynibitor, may help prevent attacks. amiodarone and hypokalemia amiodarone and hypokalemia. 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